|Relationship Between Blood Pressure and Stroke Risk in Patients
Relationship Between Blood Pressure and Stroke Risk in Patients With Symptomatic Carotid Occlusive Disease
P.M. Rothwell, S.C. Howard and J.D. Spence
Stroke 2003;34;2583-2590; originally published online Oct 30, 2003;
Stroke is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX 72514
Copyright © 2003 American Heart Association. All rights reserved. Print ISSN: 0039-2499. Online
Background and Purpose—Blood pressure lowering in patients with a previous transient ischemic attack (TIA) or stroke reduces the risk of recurrent stroke and coronary vascular events. However, there is uncertainty about the risks and benefits in patients with severe carotid occlusive disease, particularly those with a carotid occlusion or bilateral > 70% carotid stenosis in whom cerebral perfusion is often impaired and may depend directly on systemic blood pressure. Therefore, we studied the effect of carotid artery disease on the relationship between blood pressure and stroke risk in patients with recent TIA or stroke.